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IRTG / Soft Matter Science
Freiburger Materialforschungszentrum
Stefan-Meier-Str. 21
79104 Freiburg, Germany


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You are here: Home Events Prof. Joachim Dzubiella "Protein-polyelectrolyte complexation: the many facets of (bio)molecular electrostatics"

Prof. Joachim Dzubiella "Protein-polyelectrolyte complexation: the many facets of (bio)molecular electrostatics"

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Physikalisches Institut, Universität Freiburg, Herrmann-Herder-Straße 3, 79104, Freiburg

  • Seminar
When Jul 04, 2018
from 02:15 PM to 03:00 PM
Where Seminarraum A, FMF, Stefan-Meier-Str. 21, Freiburg
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Synthetic polyelectrolytes (PEs) of various architectures are currently being exploited in a wide range of biomaterial-related applications, e.g., such as involving therapeutic agents and drug delivery systems in nanomedicine or functional coatings for biotechnological materials. In all these cases, protein adsorption is considered to be the most important factor of the interaction between the polymeric biomaterials and body fluids or tissues [1] and a better understanding of protein-PE interactions on various scales is in urgent need. In this talk, I give an overview of our recent modeling efforts, using coarse-grained computer simulations and mean-field continuum approaches, of protein adsorption to weakly-charged hydrogels [2], of protein pair complexation with a highly charged single PE chain [3] or a PE brush [4], and of the multivalent binding of proteins to highly charged dendritic PEs [5]. Comparison to calorimetry experiments for selected cases shows that the binding affinities of proteins to the PEs can be predicted by the modeling with good accuracy, providing new microscopic and mechanistic insights into PE-protein association.

[1] Wei et al., Angewandte Chemie Int. Ed. 53, 7959 (2014)
[2] Oberle et al., J. Chem. Phys. B 119, 3250 (2015)
[3] Yu et al., Soft Matter 11, 4630 (2015)
[4] Yigit et al., Langmuir 33, 417 (2016)
[5] Xu et al., Bioacromolecules 19, 409 (2018)

invited by Prof. Günter Reiter

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