Prof. Eduardo Fernández Megía "GATG Dendrimers: Bioapplications, Multivalency and Dynamics"
Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela, Spain
| What |
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| When |
Jan 21, 2015 from 02:15 PM to 03:00 PM |
| Where | Seminarraum A, FMF, Stefan-Meier-Str. 21, Freiburg |
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Our research group is interested in the development of biocompatible polymeric nanostructures for biomedical applications. With this aim, we rely on multivalent dendritic scaffolds of the GATG (Gallic Acid-Triethylene Glycol) family and their block copolymers with poly(ethylene glycol). The presence of terminal azides in GATG has allowed their easy functionalization with biologically relevant ligands by means of the Cu(I)-catalyzed azide-alkyne cycloaddition. The resulting functionalized materials have emerged as interesting tools in the study of biological processes, diagnosis, and for drug and gene delivery applications. Another area of interest in our group relates to the study of the dynamics of dendrimers by NMR relaxation, a technique that has traditionally afforded conflicting relative dynamics between the dendritic core and the periphery.
In this presentation, the preparation of GATG dendrimers and some of their biomedical applications will be shown along with a comprehensive NMR relaxation study on the dynamics of dendrimers that shows profound differences between the relaxation behaviour of dendrimers and linear polymers.
1 (a) Amaral, S. P.; Fernandez-Villamarin, M.; Correa, J.; Riguera, R.; Fernandez-Megia, E. Org. Lett. 2011, 13, 4522. (b) Fernandez-Megia, E.; Correa, J.; Rodríguez-Meizoso, I.; Riguera, R. Macromolecules 2006, 39, 2113.
2 (a) Munoz, E. M.; Correa, J.; Riguera, R.; Fernandez-Megia, E. J. Am. Chem. Soc. 2013, 135, 5966. (b) de la Fuente, M.; Raviña, M.; Sousa-Herves, A.; Correa, J.; Riguera, R.; Fernandez-Megia, E.; Sánchez, A.; Alonso, M. J. Nanomedicine 2012, 7, 1667. (c) Albertazzi, L.; Fernandez-Villamarin, M.; Riguera, R.; Fernandez-Megia, E. Bioconjugate Chem. 2012, 23, 1059. (d) Fernández-Trillo, F.; Pacheco-Torres, J.; Correa, J.; Ballesteros, P.; Lopez-Larrubia, P.; Cerdán, S.; Riguera, R.; Fernandez-Megia, E. Biomacromolecules 2011, 12, 2902.
3 (a) Pinto, L. F.; Riguera, R.; Fernandez-Megia, E. J. Am. Chem. Soc. 2013, 135, 11513. (b) Pinto, L. F.; Correa, J.; Martin-Pastor, M.; Riguera, R.; Fernandez-Megia, E. J. Am. Chem. Soc. 2013, 135, 1972.