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Stefan-Meier-Str. 21
79104 Freiburg, Germany

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You are here: Home Events Prof. Rainer Haag "Multivalent Nanosystems as Potent Inhibitors for Pathogens"

Prof. Rainer Haag "Multivalent Nanosystems as Potent Inhibitors for Pathogens"

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Institute of Chemistry and Biochemistry, Freie Universität Berlin

What
  • Seminar
When Nov 15, 2017
from 02:15 PM to 03:00 PM
Where Seminarraum A, FMF, Stefan-Meier-Str. 21, Freiburg
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Multivalency is a ubiquitous phenomenon in nature involving complex binding mechanisms for achieving non-covalent strong yet reversible interactions. Interfacial multivalent interactions at pathogen-cell interfaces (left) can be competitively inhibited by multivalent scaffolds (right) that prevent pathogen adhesion to the cells during the initial stages of infection, while monovalent inhibition fails to inhibit the biological pathway (middle). The lack in understanding of complex biological systems makes the design of an efficient multivalent inhibitor a toilsome task and is the reason why as of yet no multivalent anti-infective has emerged on the market until now. This talk will focus on the design and application of multivalent nanosystems as potent inhibitors for pathogens.

1) Mammen, Whitesides Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors. Angew. Chem. Int. Ed. 1998 (37) 2754-2794. Fasting, Haag et al. Multivalency as a chemical organization and action principle. Angew. Chem. Int. Ed. 2012 (51) 10472-10498.
2) Papp, Haag et al. Inhibition of influenza virus activity by multivalent glycoarchitectures with matched sizes. ChemBioChem: a European journal of chemical biology 2011 (12) 887-895.
3) Vonneman, Haag et al. Size-dependence of steric shielding and multivalency effects for globular binding inhibitors. J. Am. Chem. Soc. 2015 (137) 2572-2579.
4) Qi, Seeberger, Haag et al. Multivalency at Interfaces: Supramolecular Carbohydrate-Functionalized Graphene Derivatives for Bacterial Capture, Release, and Disinfection. Nano Lett. 2015 (15) 6051–6057.
5) Ziem, Azab, Osterrieder, Haag, et al. Size-dependent inhibition of herpesvirus cellular entry by polyvalent nanoarchitectures. Nanoscale 2017, 9, 3774-3783.
6) Bhatia, Lauster, Bardua, Ludwig, Angioletti-Uberti, Popp, Hoffmann, Paulus, Budt, Stadtmüller, Wolff, Hamann, Böttcher, Herrmann, Haag, Linear polysialoside outperforms dendritic analogs for inhibition of influenza virus infection in vitro and in vivo. Biomaterials 2017, (138), 22-34.

 

invited by Martin Gotthardt & Steffen Wiedmann

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