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IRTG / Soft Matter Science
Freiburger Materialforschungszentrum
Stefan-Meier-Str. 21
79104 Freiburg, Germany

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You are here: Home Events Prof. Michael Mayer "Characterization of Single Proteins in Nanopores"

Prof. Michael Mayer "Characterization of Single Proteins in Nanopores"

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Adolphe Merkle Institute, Chair Biophysics, University of Fribourg, Switzerland

  • Seminar
When Jun 21, 2017
from 02:15 PM to 03:15 PM
Where Seminarraum A, FMF, Stefan-Meier-Str. 21, Freiburg
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This talk describes the use of electrolyte-filled nanopores with self-assembled lipid membrane coatings to determine, simultaneously and in real time, the shape, volume, charge, rotational diffusion coefficient, and dipole moment of individual proteins and protein complexes in solution.  The talk introduces the main concepts for a quantitative understanding and analysis of modulations in ionic current that arise from rotational dynamics of single proteins as they move through the electric field inside a nanopore.  The resulting multi-parametric information raises the possibility to characterize, identify, and count individual proteins and protein complexes in a mixture with implications for protein folding studies, biomarker detection, and routine protein analysis.


invited by Jan Behrends

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