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IRTG / Soft Matter Science
Freiburger Materialforschungszentrum
Stefan-Meier-Str. 21
79104 Freiburg, Germany

Contact: Jana Husse

+49 761 203 678 34
softmattergraduate[at]uni-freiburg.de


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You are here: Home Events Dr. Jens Elgeti "Growing and active materials"

Dr. Jens Elgeti "Growing and active materials"

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Forschungszentrum Jülich, Institute of Complex Systems, Jülich, Germany

What
  • Seminar
When Feb 10, 2016
from 02:15 PM to 03:00 PM
Where Seminarraum A, FMF, Stefan-Meier-Str. 21, Freiburg
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Growth of solid tumors or metastasis requiers, besides massive biomedical changes, also a spatial remodeling of the tissue. This remodeling, often including displacements of healthy tissue around, requires mechanical work to be done. These mechanics of growth has attracted a lot of attention in recent years, but still remains poorly understood.

We use particle based simulations to study mechanical properties and effects in growing and motile tissues. These simulations have been helpful in understanding, interpreting and designing experiments. I will present an overview of the simulation thechnique, and how it contributed to recent developments in three dimensional tissue growth and collective cell migration. In a recent series of simulations and close experimental collaborations we found important interfacial and surface effects that lead to novel phenomena. For example, the tissue divides favorably at a free surface, even without any nutrient effects. This leads to the possibility and stability of a negative homeostatic pressure. In turn, a negative homeostatic pressure leads to naturally to finite steady states and tensile states.

References:
[1] N. Podewitz et al, EPL 109: 58005(2015)
[2] T. Marel et al, NJPhys 16: 115005(2014)
[3] M.Basan et al, PNAS 110:  2452 (2013)
[4] F. Montel et al, N. J. Phys. 14: 055008 (2012)
[5] F. Montel  et al, Phys. Rev. Lett. 107: 188102, (2011)
[6] M. Basan et al, Phys. Biol. 8: 026014, (2011)

 

invited by PD Dr. Falko Ziebert

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