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IRTG / Soft Matter Science
Freiburger Materialforschungszentrum
Stefan-Meier-Str. 21
79104 Freiburg, Germany

Contact: Jana Husse

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softmattergraduate[at]uni-freiburg.de


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You are here: Home Events Dr. Sebastian Koltzenburg "Bioavailability of Poorly Soluble Actives. Chemistry, Physics, and Processes"

Dr. Sebastian Koltzenburg "Bioavailability of Poorly Soluble Actives. Chemistry, Physics, and Processes"

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BASF, Lugwigshafen

What
  • Seminar
When Oct 30, 2013
from 02:15 PM to 03:00 PM
Where Seminarraum A, FMF, Stefan-Meier-Str. 21, Freiburg
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Poor solubility of new drug candidates represents an ever increasing challenge to the pharmaceutical industry. According to estimations, up to 90% of all new chemical entities fall into this category thus challenging the formulator’s skills. To overcome this issue, both chemical and physical pathways can be chosen to either increase the apparent solubility or the dissolution rate of a poorly soluble drug. This presentation will show novel polymer-based approaches for the solubilization of “brick-dust”. 

One approach relies on the use of a newly developed polymeric solubilizer. The product is an amphiphilic copolymer based on vinyl caprolactam, vinyl acetate, and poly(ethylene glycol), and has been cleared for use in pharmaceuticals. It will be shown that both solubility and bioavailability of poorly soluble drugs can be increased by up to several hundred percent using this polymeric additive.

Alternatively (or in addition) to the use of solubilizing polymers, the dissolution of poorly soluble compounds can be effectively enhanced by going to the nanoscale and increasing the dissolution rate (rather than the equilibrium solubility) of a pharmaceutical formulation.
 

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