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You are here: Home Events Prof. Hans Börner "Programming and regulating self-assembly of biohybrid polymers: Routes to enlarge the structural and functional space of soft matter"

Prof. Hans Börner "Programming and regulating self-assembly of biohybrid polymers: Routes to enlarge the structural and functional space of soft matter"

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Humboldt Universität zu Berlin

What
  • Seminar
When Feb 22, 2011
from 10:30 AM to 11:15 AM
Where « Amphithéâtre de l’Institut Charles Sadron», 23 rue du Loess, 67034 Strasbourg
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h.boerner@chemie.hu-berlin.de

Abstract

The combination of monomer‐sequence defined peptides and synthetic polymers proved to result in an interesting class of multifunctional block copolymers.[1,2] The defined amino acid sequence of peptides allows for encoding specific information into such peptide‐polymer conjugates.[3]

While the generation of specific functions in bioconjugates i. e. programming the self‐assembly of bioconjugates has been in the focus of prior work,[4,5] the regulation of such functions get mandatory.[6] For instance, the peptide‐guided organization process of bioconjugates was developed further by introducing a “switch” concept that allows to control the rates of aggregation via pH.[7] This provides a handle to regulate the aggregation kinetics of bioconjugates in water and organic solvents.[7‐9] With respect to the design of potent regulative mechanisms enzymatic processing has been evaluated, too. Based on this, a “BioSwitch” strategy was established that utilizes enzymes to specifically modulate properties of peptide segments in peptide‐polymer conjugates.[10] Moreover Calcium ions have been exploited as triggers to screen peptide charges, amplification of the effect was found by switching the peptide secondary structure that leads to reversible control of self‐assembly of bioconjugates. Disassembly was feasible by controlling the Ca2+‐levels via competitive Ca2+‐binders.[11]

1. Börner, H. G. Macromol. Rapid Commun. 2011, Special Issue on "Precision Polymers"; Lutz, J.‐F. and Börner H.G. (Eds.), DOI = 10.1002/marc.201000646.
2. Börner, H. G. Prog. Polym. Sci. 2009, 34, 811.
3. Hentschel, J.; Bleek, K.; Ernst, O.; Lutz, J.‐F.; Börner, H. G. Macromolecules 2008, 41, 1073.
4. ten Cate, M. G. J.; Severin, N.; Börner, H. G. Macromolecules 2006, 39, 7831.
5. Eckhardt, D.; Groenewolt, M.; Krause, E.; Börner, H. G. Chem. Commun. 2005, 2814.
6. Börner, H. G.; Kühnle, H.; Hentschel, J. J. Polym. Sci., Part A: Polym. Chem. 2010, 48, 1.
7. Hentschel, J.; Börner, H. G. J. Am. Chem. Soc. 2006, 128, 14142.
8. Hentschel, J.; Krause, E.; Börner, H. G. J. Am. Chem. Soc. 2006, 128 7722
9. Hentschel, J.; ten Cate, M. G. J.; Börner, H. G. Macromolecules 2007, 40, 9224.
10. Kühnle, H.; Börner, H. G. Angew. Chem., Int. Ed. 2009, 48, 6431.
11. Kühnle, R. I.; Börner, H. G. 2011, submitted.

 

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