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IRTG / Soft Matter Science
Freiburger Materialforschungszentrum
Stefan-Meier-Str. 21
79104 Freiburg, Germany

Contact: Jana Husse

+49 761 203 678 34
softmattergraduate[at]uni-freiburg.de


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You are here: Home Events Prof. Robert Liska "Biocompatible Polymers in Tissue Engineering"

Prof. Robert Liska "Biocompatible Polymers in Tissue Engineering"

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Institute of Applied Synthetic Chemistry, Vienna University of Technology, Austria

What
  • Seminar
When May 13, 2014
from 02:15 PM to 03:00 PM
Where Hörsaal Makromolekulare Chemie, Stefan-Meier-Str. 31
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Photocuring has gained increasing interest in recent years for the curing of hydrogels in tissue engineering applications, but toxicity of acrylate-based monomers is still a limitation. Very recently we have demonstrated that vinylesters  and vinylcarbonates  are a promising class of new, low toxic monomers not only for biomedical applications. The only limitation of moderate reactivity between those of methacrylates and acrylates has been circumvented by thiol-ene polymerization.  It has been proven by cytotoxicity measurements that most of the multifunctional thiols have very low cytotoxicity.

For the 3D printing process, the rather new two photon polymerization technique has also gained increasing interest during the last year. Especially the recently demonstrated significant increase in writing speed will make it nowadays interesting for translation into industrial processes.  With newly designed two photon initiators we were also able to show the 3D printing of vinylester-modified gelatine with free thiol-groups of bovine serum albumin, for potential tissue engineering application. Other suitable polymer substrates that were modified with low toxic reactive groups belong to natural polymers like hyaluronic acid or synthetic polymers like polyvinyl alcohol. By multi-photon grafting one is able to make site-selective modifications of hydrogels in the µm scale.

For real-time study of the photocuring behaviour a special setup based on a combination of photorheometry coupled with an FTIR spectrometer will be presented.


  B. Husaar, R. Liska; Chem Soc Rev 2012;41(6):2395-2405
  C. Heller, M. Schwentenwein, G. Russmüller, T. Koch, D. Moser, C. Schopper, F. Varga, J. Stampfl, R. Liska: J Polym Sci, Polym Chem 49 (2011), 3; 650 - 661.
  R. Liska, X.H. Qin, A. Mautner US provisional application: 61/542,522;
  http://www.bbc.co.uk/news/technology-17357374
 

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