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IRTG / Soft Matter Science
Freiburger Materialforschungszentrum
Stefan-Meier-Str. 21
79104 Freiburg, Germany

Contact: Jana Husse

+49 761 203 678 34
softmattergraduate[at]uni-freiburg.de


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You are here: Home Events Prof. Dr. Helmut Schiessel "The Mechanical Genome"

Prof. Dr. Helmut Schiessel "The Mechanical Genome"

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Theoretical Physics of Life Processes Instituut-Lorentz for Theoretical Physics University of Leiden, The Netherlands

What
  • Seminar
When Jun 29, 2016
from 02:15 PM to 03:00 PM
Where Seminarraum A, FMF, Stefan-Meier-Str. 21, Freiburg
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In this talk I will show that DNA molecules contain another layer of information on top of the classical genetic information. This different type of information is of mechanical nature and guides the folding of the DNA molecule inside the cells. The two layers can be multiplexed without loss of information as one can have two phone conversations on the same wire. We have developed a new Monte Carlo technique, the Mutation Monte Carlo method, that allows us to address this set of problems. Using this technique, I will show how mechanical information can be used to guide, with base-pair precision, the packaging of DNA into nucleosomes, ubiquitous DNA-protein complexes that wrap about three quarter of our DNA at any given time. I will also show how we can design nucleosomes with exotic mechanical properties. Our findings suggest that there is a mechanical evolution of DNA molecules that takes place parallel to the classical evolution.

 

invited by Maxim Dolgushev

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