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IRTG / Soft Matter Science
Freiburger Materialforschungszentrum
Stefan-Meier-Str. 21
79104 Freiburg, Germany

Contact: Jana Husse

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You are here: Home Events Prof. Jan de Boer "Engineering the biology of bone regeneration"

Prof. Jan de Boer "Engineering the biology of bone regeneration"

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Laboratory of Cell Biology-inspired Tissue Engineering, Merln Institute of Technology-driven Regenerative Medicine, Maastricht University, The Netherlands

  • Seminar
When Jan 07, 2015
from 02:45 PM to 03:30 PM
Where Seminarraum A, FMF, Stefan-Meier-Str. 21, Freiburg
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Research in our laboratory is dedicated to understanding and applying basic cell biological principles in the field of biomedical engineering, in particular in the regeneration of bone tissue. The research program is characterized by a holistic approach to both discovery and application, aiming at combining high throughput technologies, computational modeling and experimental cell biology to streamline the wealth of biological knowledge to real clinical applications.

In my seminar I will discuss our recent work on signal transduction in mesenchymal stem cells and osteoblast, induced by either candidate small molecules or molecules extracted from small molecule screens. Enhanced performance of the cells in vitro led to increased tissue formation in vivo. I will also discuss the interaction of cells with biomaterials. For instance, we are interested in the bone-inducing properties of a subset of porous calcium phosphate ceramics and show how through reverse engineering, we are uncovering an interesting and complex response of cells to materials. Inspired by this, we have started to design high throughput screening strategies of biomaterials libraries, and in particular libraries of surface topographies. Using a design algorithm, we have generated numerous different patterns, which can first be reproduced on a silicon mold and then imprinted onto polymers using microfabrication. After cell seeding, we use quantitative high content imaging and machine learning algorithms to characterize the response of the cells to the thousands of different surfaces and learn more about the relation between surface topography and cell response. For instance, we have screened for surfaces which stimulate osteogenic differentiation of mesenchymal stem cells, surfaces which could potentially be applied on the surface of materials used in orthopedic research.

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