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IRTG / Soft Matter Science
Freiburger Materialforschungszentrum
Stefan-Meier-Str. 21
79104 Freiburg, Germany

Contact: Jana Husse

+49 761 203 678 34
softmattergraduate[at]uni-freiburg.de


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You are here: Home Events Prof. Alexander Rohrbach "Cellular biophysics on the small and fast scale"

Prof. Alexander Rohrbach "Cellular biophysics on the small and fast scale"

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Department of Microsystems Engineering (IMTEK), University of Freiburg

What
  • Seminar
When May 06, 2015
from 02:15 PM to 03:00 PM
Where Seminarraum A, FMF, Stefan-Meier-Str. 21
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Living cells are highly complex systems, which are continuously out of thermodynamic equilibrium. The resulting forces drive cellular structures on all temporal and spatial scales inside living cells. The smaller the structures to be investigated, the faster they usually move, because of both thermal motion and coordinated work of molecular motors.

In this talk I will discuss several molecular structures undergoing complex motions inside living macrophages and bacteria. I will demonstrate how fluorescence-based super resolution microscopy uncovers the work of polymerization motors driving the cytoskeleton in bacteria. I will further show how fast shape changes of a tiny helical bacterium held in a scanning optical trap can be monitored in 3D at 1000 Hz giving insights of molecular processes inside the 200 nm thin cell body.

I will make the switch to a novel coherent super-resolving imaging mode, which reveals unexpected biophysical transport and reorganization processes at the periphery of macrophages. Active transport processes as well as diffusional processes of small particles at the cell periphery can be investigated on a molecular scale using optical traps and 1MHz particle tracking, which uncover various physics mechanisms relevant for biology.

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